Article
Multiple cells-of-origin of mutant K-Ras-induced mouse lung adenocarcinoma.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2014
Sutherland Kate D, Song Ji-Ying, Kwon Min Chul, Proost Natalie, Zevenhoven John, Berns Anton
Abstract excerpt
Much controversy surrounds the cell-of-origin of mutant K-Ras (K-RasG12D)-induced lung adenocarcinoma. To shed light on this issue, we have used technology that enables us to conditionally target K-RasG12D expression in Surfactant Protein C (SPC)(+) alveolar type 2 cells and in Clara cell antigen 10 (CC10)(+) Clara cells by use of cell-type-restricted recombinant Adeno-Cre viruses. Experiments were performed both...
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