Article
Immunoregulatory cytokines gene polymorphisms in Egyptian patients affected with acquired aplastic anemia.
Annals of hematology - 1 Jun 2014
El Mahgoub Iman R, Afify Reham A Aleem, Botros Shahira K A, Fawzy Rania
Abstract excerpt
The immune system is thought to play an important role in aplastic anemia (AA) in light of recent findings of hematologic reconstitution after immunosuppressive therapy. T cell activation, apoptosis, and the cytokines interferon- and TNF-α are suspected to play a role in the suppression of growth of progenitor cells and induced apoptosis in CD34 target cells, TGFβ is a multifunctional peptide, usually produced in...
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