Polymorphisms in the immunoregulatory genes are associated with hematopoietic recovery and increased susceptibility to bacterial infections in patients with thalassaemia major undergoing matched related hematopoietic stem cell transplantation.

doi:10.1016/j.bbmt.2012.01.011

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Article

Polymorphisms in the immunoregulatory genes are associated with hematopoietic recovery and increased susceptibility to bacterial infections in patients with thalassaemia major undergoing matched related hematopoietic stem cell transplantation.

Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Aug 2012

Sellathamby Shanmugaapriya, Lakshmi Kavitha M, Busson Marc, Viswabandya Auro, George Biju, Mathews Vikram, Chandy Mammen, Charron Dominique, Krishnamoorthy Rajagopal, Tamouza Ryad, Srivastava Alok

Abstract excerpt

In this study, the impact of polymorphisms in the genes of proinflammatory (IL-β, TNF-α, IL-6, IFN-γ), anti-inflammatory (transforming growth factor [TGF]-β, IL-10, IL-Ra), and other immunoregulatory factors (FcγRIIa, NOS3) along with the conventional risk factors on the rate of hematopoietic recovery and first episodes of bacterial, viral, or invasive fungal infections in 102 patients with β-thalassaemia major...

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PMID: 22252124
DOI: 10.1016/j.bbmt.2012.01.011

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NOS3

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