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Article

The complex pathophysiology of acquired aplastic anaemia.

Clinical and experimental immunology - 1 Jun 2015

Zeng Y, Katsanis E

Abstract excerpt

Immune-mediated destruction of haematopoietic stem/progenitor cells (HSPCs) plays a central role in the pathophysiology of acquired aplastic anaemia (aAA). Dysregulated CD8(+) cytotoxic T cells, CD4(+) T cells including T helper type 1 (Th1), Th2, regulatory T cells and Th17 cells, natural killer (NK) cells and NK T cells, along with the abnormal production of cytokines including interferon (IFN)-γ, tumour...

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Anemia, Aplastic
Cytokines
Disease Susceptibility
Hematopoietic Stem Cells
Immunity, Innate
Immunomodulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mesenchymal Stem Cells

T-Lymphocyte Subsets

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Identifiers

PMID: 25683099
DOI: 10.1111/cei.12605
PMCID: PMC4449765

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TNF

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