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Current Concepts of the Pathogenesis of Aplastic Anemia

13 Mar 2019

Abstract excerpt

Abnormal activation of the immune system plays an important role in the pathogenesis of aplastic anemia (AA). Various immune cells and cytokines constitute a complex immune network, leading to bone marrow failure. The known pathogenesis is an increase of the myeloid dendritic cell (mDC)/ plasmacytoid dendritic cell (pDC) ratio, which causes the ratio of T helper (Th)1/Th2 to be skewed in favor of Th1 and...

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PMID: 30864496
DOI: 10.2174/1381612825666190313113601

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