In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing.

doi:10.1016/j.jacc.2013.11.023

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Article

In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing.

Journal of the American College of Cardiology - 22 Apr 2014

Courties Gabriel, Heidt Timo, Sebas Matthew, Iwamoto Yoshiko, Jeon Derrick, Truelove Jessica, Tricot Benoit, Wojtkiewicz Greg, Dutta Partha, Sager Hendrik B, Borodovsky Anna, Novobrantseva Tatiana, Klebanov Boris, Fitzgerald Kevin, Anderson Daniel G, Libby Peter, Swirski Filip K, Weissleder Ralph, Nahrendorf Matthias

Abstract excerpt

OBJECTIVES: The aim of this study was to test whether silencing of the transcription factor interferon regulatory factor 5 (IRF5) in cardiac macrophages improves infarct healing and attenuates post-myocardial infarction (MI) remodeling. BACKGROUND: In healing wounds, the M1 toward M2 macrophage phenotype transition supports resolution of inflammation and tissue repair. Persistence of inflammatory M1 macrophages...

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Identifiers

PMID: 24361318
DOI: 10.1016/j.jacc.2013.11.023
PMCID: PMC3992176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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