Article
Irf5 Knockdown in Bone Marrow-Derived Macrophages Favors M1-to-M2 Transition.
Cells - 26 Jan 2026
Petrova Elizaveta, Sherstyukova Ekaterina, Kandrashina Snezhanna, Inozemtsev Vladimir, Tsitrina Alexandra, Fedorova Viktoriya, Shvedov Mikhail, Kuzovlev Artem, Dokukin Maxim, Kotelevtsev Yuri, Mikaelyan Arsen, Sergunova Viktoria
Abstract excerpt
The transcription factor IRF5 maintains macrophages in the pro-inflammatory M1 state. We assessed the effects of siRNA-mediated knockdown of Irf5 on murine bone marrow-derived macrophages (BMDM) in M0, M1 and M2 states. Knockdown of Irf5 in M1 macrophages made them phenotypically similar to M2 macrophages, which was reflected in the decreased expression of the M1 marker iNOS, increased expression of the M2 marker...
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