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Article

Differential effects of Smad2 and Smad3 in regulation of macrophage phenotype and function in the infarcted myocardium.

Journal of molecular and cellular cardiology - 1 Oct 2022

Chen Bijun, Li Ruoshui, Hernandez Silvia C, Hanna Anis, Su Kai, Shinde Arti V, Frangogiannis Nikolaos G

Abstract excerpt

TGF-βs regulate macrophage responses, by activating Smad2/3. We have previously demonstrated that macrophage-specific Smad3 stimulates phagocytosis and mediates anti-inflammatory macrophage transition in the infarcted heart. However, the role of macrophage Smad2 signaling in myocardial infarction remains unknown. We studied the role of macrophage-specific Smad2 signaling in healing mouse infarcts, and we explored...

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Source

Identifiers

PMID: 35780861
DOI: 10.1016/j.yjmcc.2022.06.009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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