Article

CRISPR-Cas9 Editing of TLR4 to Improve the Outcome of Cardiac Cell Therapy

2022-07-12

Abstract excerpt

<h4>Background: </h4> Inflammation and fibrosis limit the reparative properties of human mesenchymal stromal cells (hMSCs). We hypothesized that disrupting the toll-like receptor 4 (TLR4) gene would switch hMSCs toward a reparative phenotype and improve the outcome of cell therapy for infarct repair. <h4>Methods: </h4> and results: We developed and optimized a new electroporation protocol for CRISPR-Cas9 gene edit...

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Literature Corpus work: 551e28a3-b730-5ae8-9348-c68bb86e3d51
DOI: 10.21203/rs.3.rs-1823485/v1

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