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Genetic modification and screening in rat using haploid embryonic stem cells.

Cell stem cell - 6 Mar 2014

Li Wei, Li Xin, Li Tianda, Jiang Ming-Gui, Wan Haifeng, Luo Guan-Zheng, Feng Chunjing, Cui Xiaolong, Teng Fei, Yuan Yan, Zhou Quan, Gu Qi, Shuai Ling, Sha Jiahao, Xiao Yamei, Wang Liu, Liu Zhonghua, Wang Xiu-Jie, Zhao Xiao-Yang, Zhou Qi

Abstract excerpt

The rat is an important animal model in biomedical research, but practical limitations to genetic manipulation have restricted the application of genetic analysis. Here we report the derivation of rat androgenetic haploid embryonic stem cells (RahESCs) as a tool to facilitate such studies. Our approach is based on removal of the maternal pronucleus from zygotes to generate androgenetic embryos followed by...

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Identifiers

PMID: 24360884
DOI: 10.1016/j.stem.2013.11.016

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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