Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility.

Molecular and cellular biology - 1 Nov 2003

Callahan Julie L, Andrews Kenneth J, Zakian Virginia A, Freudenreich Catherine H

Abstract excerpt

Expansion of trinucleotide repeats (TNRs) is the causative mutation in several human genetic diseases. Expanded TNR tracts are both unstable (changing in length) and fragile (displaying an increased propensity to break). We have investigated the relationship between fidelity of lagging-strand replication and both stability and fragility of TNRs. We devised a new yeast artificial chromomosme (YAC)-based assay for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Assay
Share to DNA Ligases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Polymerase III

Share to DNA Primase

Share to Flap Endonucleases

Share to Ribonuclease H

Share to Trinucleotide Repeat Expansion

Share to Yeasts

Source

Open in PubMed Open full text

Identifiers

PMID: 14560028
DOI: 10.1128/MCB.23.21.7849-7860.2003
PMCID: PMC207578

Genes

TNR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in yeast replication proteins that increase CAG/CTG expansions also increase repeat fragility.PMID 14560028Read ↗

Double-strand break repair can lead to high frequencies of deletions within short CAG/CTG trinucleotide repeats.Semantic proximity Read ↗

Expansion and Length-Dependent Fragility of CTG Repeats in YeastSemantic proximity Read ↗

Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair.Semantic proximity Read ↗

Structure-forming CAG/CTG repeats interfere with gap repair to cause repeat expansions and chromosome breaks.Semantic proximity Read ↗

Saccharomyces cerevisiae flap endonuclease 1 uses flap equilibration to maintain triplet repeat stability.Semantic proximity Read ↗

Nucleotide excision repair and the 26S proteasome function together to promote trinucleotide repeat expansions.Semantic proximity Read ↗

Genome-wide screen identifies pathways that govern GAA/TTC repeat fragility and expansions in dividing and nondividing yeast cells.Semantic proximity Read ↗

Identification of rad27 mutations that confer differential defects in mutation avoidance, repeat tract instability, and flap cleavage.Semantic proximity Read ↗

Environmental stress induces trinucleotide repeat mutagenesis in human cells.Semantic proximity Read ↗

Structure-forming CAG/CTG repeat sequences are sensitive to breakage in the absence of Mrc1 checkpoint function and S-phase checkpoint signaling: implications for trinucleotide repeat expansion diseases.Semantic proximity Read ↗

REV1 inhibition enhances trinucleotide repeat mutagenesisSemantic proximity Read ↗

New functions of Ctf18-RFC in preserving genome stability outside its role in sister chromatid cohesion.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.