Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex promotes trinucleotide repeat expansions independently of homologous recombination.

DNA repair - 1 Jul 2016

Ye Yanfang, Kirkham-McCarthy Lucy, Lahue Robert S

Abstract excerpt

Trinucleotide repeats (TNRs) are tandem arrays of three nucleotides that can expand in length to cause at least 17 inherited human diseases. Somatic expansions in patients can occur in differentiated tissues where DNA replication is limited and cannot be a primary source of somatic mutation. Instead, mouse models of TNR diseases have shown that both inherited and somatic expansions can be suppressed by the loss...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to DNA Helicases
Share to Endodeoxyribonucleases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exodeoxyribonucleases

Share to Histone Deacetylases

Share to Homologous Recombination

Share to Trinucleotide Repeat Expansion

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 27173583
DOI: 10.1016/j.dnarep.2016.04.012

Genes

TNR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex promotes trinucleotide repeat expansions independently of homologous recombination.PMID 27173583Read ↗

Nucleotide excision repair and the 26S proteasome function together to promote trinucleotide repeat expansions.Semantic proximity Read ↗

Postreplication repair inhibits CAG.CTG repeat expansions in Saccharomyces cerevisiae.Semantic proximity Read ↗

Saccharomyces cerevisiae Srs2 DNA helicase selectively blocks expansions of trinucleotide repeats.Semantic proximity Read ↗

Mismatch repair blocks expansions of interrupted trinucleotide repeats in yeast.Semantic proximity Read ↗

Genetic modifiers of repeat expansion disorders.Semantic proximity Read ↗

Expanded CAG/CTG repeat DNA induces a checkpoint response that impacts cell proliferation in Saccharomyces cerevisiae.Semantic proximity Read ↗

RTEL1 inhibits trinucleotide repeat expansions and fragility.Semantic proximity Read ↗

The 26S proteasome drives trinucleotide repeat expansions.Semantic proximity Read ↗

Histone deacetylase complexes promote trinucleotide repeat expansions.Semantic proximity Read ↗

A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and HumansSemantic proximity Read ↗

The Startling Role of Mismatch Repair in Trinucleotide Repeat Expansions.Semantic proximity Read ↗

Interruptions impact clinical features of repeat expansion diseases, but how are they gained and lost?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.