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Article

Postreplication repair inhibits CAG.CTG repeat expansions in Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Jan 2007

Daee Danielle L, Mertz Tony, Lahue Robert S

Abstract excerpt

Trinucleotide repeats (TNRs) are unique DNA microsatellites that can expand to cause human disease. Recently, Srs2 was identified as a protein that inhibits TNR expansions in Saccharomyces cerevisiae. Here, we demonstrate that Srs2 inhibits CAG . CTG expansions in conjunction with the error-free branch of postreplication repair (PRR). Like srs2 mutants, expansions are elevated in rad18 and rad5 mutants, as well...

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Share to DNA, Fungal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Expression Regulation, Fungal

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Source

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Identifiers

PMID: 17060452
DOI: 10.1128/MCB.01167-06
PMCID: PMC1800661

Genes

TNR
PCNA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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