Article
Trinucleotide repeats: mechanisms and pathophysiology.
Annual review of genomics and human genetics - 1 Jan 2000
Cummings C J, Zoghbi H Y
Abstract excerpt
Within the closing decade of the twentieth century, 14 neurological disorders were shown to result from the expansion of unstable trinucleotide repeats, establishing this once unique mutational mechanism as the basis of an expanding class of diseases. Trinucleotide repeat diseases can be categorized into two subclasses based on the location of the trinucleotide repeats: diseases involving noncoding repeats...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.