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Article

Double-strand break repair can lead to high frequencies of deletions within short CAG/CTG trinucleotide repeats.

Molecular & general genetics : MGG - 1 Jun 1999

Richard G F, Dujon B, Haber J E

Abstract excerpt

Trinucleotide repeats undergo contractions and expansions in humans, leading in some cases to fatal neurological disorders. The mechanism responsible for these large size variations is unknown, but replication-slippage events are often suggested as a possible source of instability. We constructed a genetic screen that allowed us to detect spontaneous expansions/contractions of a short trinucleotide repeat in...

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Identifiers

PMID: 10394925
DOI: 10.1007/s004380050031

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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