Article
A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential.
Blood - 30 Jan 2014
Rocanin-Arjo Ares, Cohen William, Carcaillon Laure, Frère Corinne, Saut Noémie, Letenneur Luc, Alhenc-Gelas Martine, Dupuy Anne-Marie, Bertrand Marion, Alessi Marie-Christine, Germain Marine, Wild Philipp S, Zeller Tanja, Cambien Francois, Goodall Alison H, Amouyel Philippe, Scarabin Pierre-Yves, Trégouët David-Alexandre, Morange Pierre-Emmanuel
Abstract excerpt
Thrombin, the major enzyme of the hemostatic system, is involved in biological processes associated with several human diseases. The capacity of a given individual to generate thrombin, called the thrombin generation potential (TGP), can be robustly measured in plasma and was shown to associate with thrombotic disorders. To investigate the genetic architecture underlying the interindividual TGP variability, we...
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