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High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism

31 Mar 2023

Abstract excerpt

BACKGROUND: C1-inhibitor (C1INH) is a broad-acting serine protease inhibitor with anticoagulant activity. The impact of C1INH plasma levels within the normal physiological range on risk of venous thromboembolism (VTE) is unknown. We assessed the association of plasma C1INH levels and VTE risk and evaluated the impact of C1INH on thrombin and plasmin generation in ex vivo assays. METHODS: A nested case-control...

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PMID: 37003465
DOI: 10.1016/j.jtha.2023.03.024

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