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Article

Plasma levels of complement components C5 and C9 are associated with thrombin generation.

Journal of thrombosis and haemostasis : JTH - 1 Sept 2024

Vacik Díaz Rocío, Munsch Gaëlle, Iglesias Maria Jesus, Pallares Robles Alejandro, Ibrahim-Kosta Manal, Nourse Jamie, Khan Essak, Castoldi Elisabetta, Saut Noémie, Boland Anne, Germain Marine, Deleuze Jean-François, Odeberg Jacob, Morange Pierre-Emmanuel, Danckwardt Sven, Tregouët David-Alexandre, Goumidi Louisa

Abstract excerpt

BACKGROUND: The thrombin generation assay (TGA) evaluates the potential of plasma to generate thrombin over time, providing a global picture of an individual's hemostatic balance. OBJECTIVES: This study aimed to identify novel biological determinants of thrombin generation using a multiomics approach. METHODS: Associations between TGA parameters and plasma levels of 377 antibodies targeting 236 candidate proteins...

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Source

Identifiers

PMID: 38838952
DOI: 10.1016/j.jtha.2024.04.026

Genes

C5
C9
EFS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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