Article
Identification of quantitative trait loci for fibrin clot phenotypes: the EuroCLOT study.
Arteriosclerosis, thrombosis, and vascular biology - 1 Apr 2009
Williams Frances M K, Carter Angela M, Kato Bernet, Falchi Mario, Bathum Lise, Surdulescu Gabriela, Kyvik Kirsten Ohm, Palotie Aarno, Spector Tim D, Grant Peter J
Abstract excerpt
OBJECTIVE: Fibrin makes up the structural basis of an occlusive arterial thrombus, and variability in fibrin phenotype relates to cardiovascular risk. The aims of the current study from the EU consortium EuroCLOT were to (1) determine the heritability of fibrin phenotypes and (2) identify QTLs associated with fibrin phenotypes. METHODS AND RESULTS: 447 dizygotic (DZ) and 460 monozygotic (MZ) pairs of healthy UK...
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