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A silent mutation in mabA confers isoniazid resistance on M ycobacterium tuberculosis

4 Dec 2013

Abstract excerpt

Drug resistance in Mycobacterium tuberculosis (Mtb) is caused by mutations in restricted regions of the genome. Mutations in katG, the promoter region of the mabA-inhA operon, and inhA are those most frequently responsible for isoniazid (INH) resistance. Several INH-resistant (INH(r) ) Mtb clinical isolates without mutations in these regions have been described, however, indicating that there are as yet...

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PMID: 24354762
DOI: 10.1111/mmi.12476

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