Article
The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.
Microbiology (Reading, England) - 1 Oct 1998
Banerjee Asesh, Sugantino Michele, Sacchettini James C, Jacobs William R
Abstract excerpt
A target of the anti-tuberculosis drugs isoniazid (INH) and ethionamide (ETH) has been shown to be an enoyl reductase, encoded by the inhA gene. The mabA (mycolic acid biosynthesis A) gene is located immediately upstream of inhA in Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium...
Topics
- 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase
- Alcohol Oxidoreductases
- Amino Acid Sequence
- Antitubercular Agents
- Bacterial Proteins
- Base Sequence
- Cloning, Molecular
- Conserved Sequence
- Drug Resistance, Microbial
- Ethionamide
- Genetic Vectors
- Isoniazid
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Mutation
- Mycobacterium tuberculosis
- Operon
- Oxidoreductases