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The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.

Microbiology (Reading, England) - 1 Oct 1998

Banerjee Asesh, Sugantino Michele, Sacchettini James C, Jacobs William R

Abstract excerpt

A target of the anti-tuberculosis drugs isoniazid (INH) and ethionamide (ETH) has been shown to be an enoyl reductase, encoded by the inhA gene. The mabA (mycolic acid biosynthesis A) gene is located immediately upstream of inhA in Mycobacterium tuberculosis, Mycobacterium bovis and Mycobacterium smegmatis. The MabA protein from M. tuberculosis was expressed in Escherichia coli and shown to have 3-ketoacyl...

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PMID: 9802011
DOI: 10.1099/00221287-144-10-2697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.PMID 9802011Read ↗

inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.Semantic proximity Read ↗

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Altered NADH/NAD+ ratio mediates coresistance to isoniazid and ethionamide in mycobacteria.Semantic proximity Read ↗

NADH dehydrogenase defects confer isoniazid resistance and conditional lethality in Mycobacterium smegmatis.Semantic proximity Read ↗

Activation of the Pro-drug Ethionamide Is Regulated in MycobacteriaSemantic proximity Read ↗

Mutation in Eth A protein of Mycobacterium tuberculosis conferred drug tolerance against enthinoamide in Mycobacterium smegmatis mc2155.Semantic proximity Read ↗

Inhibition of InhA activity, but not KasA activity, induces formation of a KasA-containing complex in mycobacteria.Semantic proximity Read ↗

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Crystal structure of MabA from Mycobacterium tuberculosis, a reductase involved in long-chain fatty acid biosynthesis.Semantic proximity Read ↗

Evidence towards the role of arylamine N-acetyltransferase in Mycobacterium smegmatis and development of a specific antiserum against the homologous enzyme of Mycobacterium tuberculosisSemantic proximity Read ↗

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