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Article

Downregulation of katG expression is associated with isoniazid resistance in Mycobacterium tuberculosis.

Molecular microbiology - 1 Mar 2011

Ando Hiroki, Kitao Tomoe, Miyoshi-Akiyama Tohru, Kato Seiya, Mori Toru, Kirikae Teruo

Abstract excerpt

Isoniazid (INH) is a key agent in the treatment of tuberculosis. In Mycobacterium tuberculosis, INH is converted to its active form by KatG, a catalase-peroxidase, and attacks InhA, which is essential for the synthesis of mycolic acids. We sequenced furA-katG and fabG1-inhA in 108 INH-resistant (...

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Identifiers

PMID: 21244531
DOI: 10.1111/j.1365-2958.2011.07547.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21244531-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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