Article
inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.
Science (New York, N.Y.) - 14 Jan 1994
Banerjee A, Dubnau E, Quemard A, Balasubramanian V, Um K S, Wilson T, Collins D, de Lisle G, Jacobs W R
Abstract excerpt
Isoniazid (isonicotinic acid hydrazide, INH) is one of the most widely used antituberculosis drugs, yet its precise target of action on Mycobacterium tuberculosis is unknown. A missense mutation within the mycobacterial inhA gene was shown to confer resistance to both INH and ethionamide (ETH) in...
Topics
- Amino Acid Sequence
- Bacterial Proteins
- Base Sequence
- Cloning, Molecular
- Drug Resistance, Microbial
- Ethionamide
- Genes, Bacterial
- Isoniazid
- Molecular Sequence Data
- Mutation
- Mycobacterium
- Mycobacterium bovis