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Article

inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.

Science (New York, N.Y.) - 14 Jan 1994

Banerjee A, Dubnau E, Quemard A, Balasubramanian V, Um K S, Wilson T, Collins D, de Lisle G, Jacobs W R

Abstract excerpt

Isoniazid (isonicotinic acid hydrazide, INH) is one of the most widely used antituberculosis drugs, yet its precise target of action on Mycobacterium tuberculosis is unknown. A missense mutation within the mycobacterial inhA gene was shown to confer resistance to both INH and ethionamide (ETH) in M. smegmatis and in M. bovis. The wild-type inhA gene also conferred INH and ETH resistance when transferred on a...

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Identifiers

PMID: 8284673
DOI: 10.1126/science.8284673

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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inhA, a gene encoding a target for isoniazid and ethionamide in Mycobacterium tuberculosis.PMID 8284673Read ↗

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