Article
Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jan 2014
Muda Kathrin, Bertinetti Daniela, Gesellchen Frank, Hermann Jennifer Sarah, von Zweydorf Felix, Geerlof Arie, Jacob Anette, Ueffing Marius, Gloeckner Christian Johannes, Herberg Friedrich W
Abstract excerpt
Leucine-rich repeat kinase 2 (LRRK2) is a multidomain protein implicated in Parkinson disease (PD); however, the molecular mechanism and mode of action of this protein remain elusive. cAMP-dependent protein kinase (PKA), along with other kinases, has been suggested to be an upstream kinase regulating LRRK2 function. Using MS, we detected several sites phosphorylated by PKA, including phosphorylation sites within...
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