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Pathways to Parkinson’s disease: a spotlight on 14-3-3 proteins

21 Sept 2021

Abstract excerpt

14-3-3s represent a family of highly conserved 30 kDa acidic proteins. 14-3-3s recognize and bind specific phospho-sequences on client partners and operate as molecular hubs to regulate their activity, localization, folding, degradation, and protein-protein interactions. 14-3-3s are also associated with the pathogenesis of several diseases, among which Parkinson's disease (PD). 14-3-3s are found within Lewy...

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PMID: 34548498
DOI: 10.1038/s41531-021-00230-6

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