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Article

Cross-talk between LRRK2 and PKA: implication for Parkinson's disease?

8 Feb 2017

Abstract excerpt

Evidence indicates that leucine-rich repeat kinase 2 (LRRK2) controls multiple processes in neurons and glia cells. Deregulated LRRK2 activity due to gene mutation represents the most common cause of autosomal dominant Parkinson's disease (PD). Protein kinase A (PKA)-mediated signaling is a key regulator of brain function. PKA-dependent pathways play an important role in brain homeostasis, neuronal development,...

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PMID: 28202680
DOI: 10.1042/bst20160396

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