Article
Phosphorylation-dependent 14-3-3 binding to LRRK2 is impaired by common mutations of familial Parkinson's disease.
PloS one - 1 Mar 2011
Li Xianting, Wang Qing Jun, Pan Nina, Lee Sangkyu, Zhao Yingming, Chait Brian T, Yue Zhenyu
Abstract excerpt
BACKGROUND: Recent studies show that mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are the cause of the most common inherited and some sporadic forms of Parkinson's disease (PD). The molecular mechanism underlying the pathogenic role of LRRK2 mutations in PD remains unknown. METHODOLOGY/PRINCIPAL FINDINGS: Using affinity purification and mass spectrometric analysis, we investigated phosphorylation sites and...
Topics
- 14-3-3 Proteins
- Amino Acid Substitution
- Animals
- Brain
- Cells, Cultured
- Cyclic AMP-Dependent Protein Kinases
- Family
- Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
- Mice
- Mice, Transgenic