Article

14-3-3 phosphorylation inhibits 14-3-3θ’s ability to regulate LRRK2 kinase activity

2023-05-30

Abstract excerpt

<h4>ABSTRACT</h4> LRRK2 mutations are among the most common genetic causes for Parkinson’s disease (PD), and toxicity is associated with increased kinase activity. 14-3-3 proteins are key interactors that regulate LRRK2 kinase activity. Phosphorylation of the 14-3-3θ isoform at S232 is dramatically increased in human PD brains. Here we investigate the impact of 14-3-3θ phosphorylation on its ability to regulate L...

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Literature Corpus work: 53463179-e8f3-5629-892a-5992e663ac51
DOI: 10.1101/2023.05.27.542591

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