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Article

Fluctuation analysis: can estimates be trusted?

PloS one - 1 Jan 2013

Ycart Bernard

Abstract excerpt

The estimation of mutation rates and relative fitnesses in fluctuation analysis is based on the unrealistic hypothesis that the single-cell times to division are exponentially distributed. Using the classical Luria-Delbrück distribution outside its modelling hypotheses induces an important bias on the estimation of the relative fitness. The model is extended here to any division time distribution. Mutant counts...

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Identifiers

PMID: 24349026
DOI: 10.1371/journal.pone.0080958
PMCID: PMC3857183

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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