Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system.

Abstract excerpt

K-Ras mutation is detected in over 30% of human malignancies. In particular, 90% of human pancreatic cancers are initiated by K-Ras mutation. Thus, selective elimination of K-Ras mutated cells would be a plausible strategy to prevent or cure the malignancies. In our previous reports, it has been...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Caveolin 1
• Share to Cell Transformation, Neoplastic
• Share to Endosomes