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Article

Regulation of clathrin-mediated endocytosis by p53.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Apr 2008

Endo Yoshie, Sugiyama Atsumi, Li Shun-Ai, Ohmori Kazuji, Ohata Hirokazu, Yoshida Yusuke, Shibuya Masabumi, Takei Kohji, Enari Masato, Taya Yoichi

Abstract excerpt

The p53 gene encodes a multi-functional protein to prevent tumorigenesis. Although there have been many reports of the nuclear functions of p53, little is known about the cytosolic functions of p53. Here, we found that p53 is present in cytosol as well as nuclei under unstressed conditions and binds to clathrin heavy chain (CHC). CHC is known to play a role in receptor-mediated endocytosis. Based on our findings,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18363968
DOI: 10.1111/j.1365-2443.2008.01172.x

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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