Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RIN1-Ras-ERK pathway plays an important role in carcinogenesis in colon cancer cell line LoVo.

Oncology research - 1 Jan 2011

Inoue Takeshi, Goi Takanori, Hirono Yasuo, Katayama Kanji, Yamaguchi Akio

Abstract excerpt

The RIN1 protein has SH2, three domains, and H-Ras binding domains; thus, it is presumed to be an important molecule in an intracellular signaling pathway. We examined the effect of the introduction of a membrane protein-encoding, mutated (S351A)RIN1 gene into a colon cancer. In the LoVo colon cancer cell line, endogenous RIN1 protein was strongly expressed in the cytoplasmic fraction, and the RIN1 protein in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 14-3-3 Proteins
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colonic Neoplasms

Share to Cytoplasm

Share to Fluorescent Antibody Technique

Share to Immunoprecipitation

Share to MAP Kinase Signaling System

Share to Real-Time Polymerase Chain Reaction

Source

Identifiers

PMID: 22812185
DOI: 10.3727/096504012x13340632812514

Genes

RIN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

RIN1-Ras-ERK pathway plays an important role in carcinogenesis in colon cancer cell line LoVo.PMID 22812185Read ↗

High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway.Semantic proximity Read ↗

RIG1 inhibits the Ras/mitogen-activated protein kinase pathway by suppressing the activation of Ras.Semantic proximity Read ↗

Cell proliferation and epidermal growth factor signaling in non-small cell lung adenocarcinoma cell lines are dependent on Rin1.Semantic proximity Read ↗

Extracellular p53 fragment re-enters K-Ras mutated cells through the caveolin-1 dependent early endosomal system.Semantic proximity Read ↗

Establishment and characterization of a human cell line derived from a uterine papillary serous carcinoma with wild-type p53 function.Semantic proximity Read ↗

Mechanism of VIPR1 gene regulating human lung adenocarcinoma H1299 cellsSemantic proximity Read ↗

A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK.Semantic proximity Read ↗

NDRG1 enhances the sensitivity of cetuximab by modulating EGFR trafficking in colorectal cancerSemantic proximity Read ↗

Mannose-6-phosphate/Insulin-like Growth Factor II Receptor Expression and Tumor DevelopmentSemantic proximity Read ↗

Downregulation of Rap1GAP in Human Tumor Cells Alters Cell/Matrix and Cell/Cell AdhesionSemantic proximity Read ↗

REP1 inhibits FOXO3-mediated apoptosis to promote cancer cell survival.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.