Article
Endocytosis and cancer.
Cold Spring Harbor perspectives in biology - 1 Dec 2013
Mellman Ira, Yarden Yosef
Abstract excerpt
Endocytosis entails selective packaging of cell-surface proteins, such as receptors for cytokines and adhesion components, in cytoplasmic vesicles (endosomes). The series of sorting events that determines the fate of internalized proteins, either degradation in lysosomes or recycling back to the plasma membrane, relies on intrinsic sequence motifs, posttranslational modifications (e.g., phosphorylation and...
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