Article
Paired-like homeoprotein ESXR1 acts as a sequence-specific transcriptional repressor of the human K-ras gene.
Oncogene - 1 Sept 2005
Yanagihara Masatomo, Ishikawa Susumu, Naito Masanori, Nakajima Junta, Aburatani Hiroyuki, Hatakeyama Masanori
Abstract excerpt
Gain-of-function mutation of the K-ras gene is one of the most common genetic changes in human tumors. In tumors carrying K-ras mutation, the presence of oncogenic K-Ras is necessary for maintenance of the transformed phenotype. ESXR1 is a human paired-like homeodomain-containing protein expressed primarily in the testis. In cells, the 65-kDa full-length ESXR1 protein is proteolytically processed into an...
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