Article
N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption.
Molecular and cellular biology - 1 Jun 2006
Deramaudt Therese B, Takaoka Munenori, Upadhyay Rabi, Bowser Mark J, Porter Jess, Lee Amy, Rhoades Ben, Johnstone Cameron N, Weissleder Ralph, Hingorani Sunil R, Mahmood Umar, Rustgi Anil K
Abstract excerpt
The genetic basis of pancreatic ductal adenocarcinoma, which constitutes the most common type of pancreatic malignancy, involves the sequential activation of oncogenes and inactivation of tumor suppressor genes. Among the pivotal genetic alterations are Ki-RAS oncogene activation and p53 tumor su...
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