Mutant p53 regulates cancer cell invasion in complex three-dimensional environments through mevalonate pathway-dependent Rho/ROCK signaling

Abstract excerpt

Certain mutations can confer neomorphic gain of function (GOF) activities to the p53 protein that affect cancer progression. Yet the concept of mutant p53 GOF has been challenged. Here, using various strategies to alter the status of mutant versions of p53 in different cell lines, we demonstrate that mutant p53 stimulates cancer cell invasion in three-dimensional environments. Mechanistically, mutant p53 enhances...

Topics

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• Cell Movement
• Extracellular Matrix
• Gain of Function Mutation
• Mevalonic Acid
• Neoplasm Invasiveness
• rho-Associated Kinases
• rhoA GTP-Binding Protein
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

00fc402b-9718-5e75-9631-192f8935cee7

DOI

10.1101/2024.10.13.618100