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Article

Blocking of p53-Snail Binding, Promoted by Oncogenic K-Ras, Recovers p53 Expression and function

1 Jan 2009

Abstract excerpt

Differentially from other kinds of Ras, oncogenic K-Ras, which is mutated approximately 30% of human cancer, does not induce apoptosis and senescence. Here, we provide the evidence that oncogenic K-Ras abrogates p53 function and expression through induction of Ataxia telangiectasia-mutated and Rad3-related mediated Snail stabilization. Snail directly binds to DNA binding domain of p53 and diminishes the...

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Identifiers

PMID: 19107228
DOI: 10.1593/neo.81006

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Blocking of p53-Snail Binding, Promoted by Oncogenic K-Ras, Recovers p53 Expression and functionPMID 19107228Read ↗

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