Article
Mutant p53 upregulates alpha-1 antitrypsin expression and promotes invasion in lung cancer.
Oncogene - 1 Aug 2017
Shakya R, Tarulli G A, Sheng L, Lokman N A, Ricciardelli C, Pishas K I, Selinger C I, Kohonen-Corish M R J, Cooper W A, Turner A G, Neilsen P M, Callen D F
Abstract excerpt
Missense mutations in the TP53 tumor-suppressor gene inactivate its antitumorigenic properties and endow the incipient cells with newly acquired oncogenic properties that drive invasion and metastasis. Although the oncogenic effect of mutant p53 transcriptome has been widely acknowledged, the global influence of mutant p53 on cancer cell proteome remains to be fully elucidated. Here, we show that mutant p53...
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