Article
HipA-mediated antibiotic persistence via phosphorylation of the glutamyl-tRNA-synthetase.
Nature communications - 1 Jan 2013
Kaspy Ilana, Rotem Eitan, Weiss Noga, Ronin Irine, Balaban Nathalie Q, Glaser Gad
Abstract excerpt
Bacterial persistence has been shown to be an underlying factor in the failure of antibiotic treatments. Although many pathways, among them the stringent response and toxin-antitoxin modules, have been linked to antibiotic persistence, a clear molecular mechanism for the growth arrest that characterizes persistent bacteria remained elusive. Here, we screened an expression library for putative targets of HipA, the...
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