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Article

HipBA-promoter structures reveal the basis of heritable multidrug tolerance.

Nature - 6 Aug 2015

Schumacher Maria A, Balani Pooja, Min Jungki, Chinnam Naga Babu, Hansen Sonja, Vulić Marin, Lewis Kim, Brennan Richard G

Abstract excerpt

Multidrug tolerance is largely responsible for chronic infections and caused by a small population of dormant cells called persisters. Selection for survival in the presence of antibiotics produced the first genetic link to multidrug tolerance: a mutant in the Escherichia coli hipA locus. HipA encodes a serine-protein kinase, the multidrug tolerance activity of which is neutralized by binding to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26222023
DOI: 10.1038/nature14662
PMCID: PMC7502270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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