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Article

The HicA toxin from Burkholderia pseudomallei has a role in persister cell formation.

The Biochemical journal - 15 Apr 2014

Butt Aaron, Higman Victoria A, Williams Christopher, Crump Matthew P, Hemsley Claudia M, Harmer Nicholas, Titball Richard W

Abstract excerpt

TA (toxin-antitoxin) systems are widely distributed amongst bacteria and are associated with the formation of antibiotic tolerant (persister) cells that may have involvement in chronic and recurrent disease. We show that overexpression of the Burkholderia pseudomallei HicA toxin causes growth arrest and increases the number of persister cells tolerant to ciprofloxacin or ceftazidime. Furthermore, our data show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24502667
DOI: 10.1042/BJ20140073
PMCID: PMC3969222

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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