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Article

Molecular mechanism of bacterial persistence by HipA.

Molecular cell - 24 Oct 2013

Germain Elsa, Castro-Roa Daniel, Zenkin Nikolay, Gerdes Kenn

Abstract excerpt

HipA of Escherichia coli is a eukaryote-like serine-threonine kinase that inhibits cell growth and induces persistence (multidrug tolerance). Previously, it was proposed that HipA inhibits cell growth by the phosphorylation of the essential translation factor EF-Tu. Here, we provide evidence that EF-Tu is not a target of HipA. Instead, a genetic screen reveals that the overexpression of glutamyl-tRNA synthetase...

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Identifiers

PMID: 24095282
DOI: 10.1016/j.molcel.2013.08.045

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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