Article
Molecular mechanisms and clinical implications of bacterial persistence.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Nov 2016
Michiels Joran Elie, Van den Bergh Bram, Verstraeten Natalie, Michiels Jan
Abstract excerpt
Any bacterial population harbors a small number of phenotypic variants that survive exposure to high concentrations of antibiotic. Importantly, these so-called 'persister cells' compromise successful antibiotic therapy of bacterial infections and are thought to contribute to the development of antibiotic resistance. Intriguingly, drug-tolerant persisters have also been identified as a factor underlying failure of...
Topics
- Anti-Bacterial Agents
- Bacteria
- Bacterial Infections
- Clone Cells
- Drug Resistance, Multiple, Bacterial
- Drug Resistance, Neoplasm
- Gene-Environment Interaction
- Genetic Heterogeneity
- Humans
- Mutation
- Neoplasms
- Phenotype
- Selection, Genetic
- Stochastic Processes
- Stress, Physiological
- Toxin-Antitoxin Systems