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Article

Bacterial persistence to antibiotics activated by tRNA mutations.

The Journal of antimicrobial chemotherapy - 4 Nov 2024

Park Jongwook, Lee Dongju, Yi Hyojeong, Yun Cheol-Won, Kim Heenam Stanley

Abstract excerpt

OBJECTIVES: Bacterial persistence is a significant cause of the intractability of chronic and relapsing infections. Despite its importance, many of the underlying mechanisms are still not well understood. METHODS: Antibiotic-tolerant mutants of Burkholderia thailandensis were isolated through exposure to lethal doses of AMP or MEM, followed by whole-genome sequencing to identify mutations. Subsequently, these...

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PMID: 39225038
DOI: 10.1093/jac/dkae307

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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