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Article

HIV-1 replication fitness of HLA-B*57/58:01 CTL escape variants is restored by the accumulation of compensatory mutations in gag.

PloS one - 1 Jan 2013

Gijsbers Esther F, Feenstra K Anton, van Nuenen Ad C, Navis Marjon, Heringa Jaap, Schuitemaker Hanneke, Kootstra Neeltje A

Abstract excerpt

Expression of HLA-B*57 and the closely related HLA-B*58:01 are associated with prolonged survival after HIV-1 infection. However, large differences in disease course are observed among HLA-B*57/58:01 patients. Escape mutations in CTL epitopes restricted by these HLA alleles come at a fitness cost and particularly the T242N mutation in the TW10 CTL epitope in Gag has been demonstrated to decrease the viral...

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Share to Disease Progression
Share to gag Gene Products, Human Immunodeficiency Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to T-Lymphocytes, Cytotoxic

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Source

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Identifiers

PMID: 24339913
DOI: 10.1371/journal.pone.0081235
PMCID: PMC3855271

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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