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Article

Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome.

Retrovirology - 30 Oct 2012

Song Hongshuo, Pavlicek Jeffrey W, Cai Fangping, Bhattacharya Tanmoy, Li Hui, Iyer Shilpa S, Bar Katharine J, Decker Julie M, Goonetilleke Nilu, Liu Michael K P, Berg Anna, Hora Bhavna, Drinker Mark S, Eudailey Josh, Pickeral Joy, Moody M Anthony, Ferrari Guido, McMichael Andrew, Perelson Alan S, Shaw George M, Hahn Beatrice H, Haynes Barton F, Gao Feng

Abstract excerpt

BACKGROUND: A modest change in HIV-1 fitness can have a significant impact on viral quasispecies evolution and viral pathogenesis, transmission and disease progression. To determine the impact of immune escape mutations selected by cytotoxic T lymphocytes (CTL) on viral fitness in the context of...

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Share to Epitopes, T-Lymphocyte
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to gag Gene Products, Human Immunodeficiency Virus

Share to Genetic Fitness

Share to Immune Evasion

Share to rev Gene Products, Human Immunodeficiency Virus

Share to T-Lymphocytes, Cytotoxic

Share to tat Gene Products, Human Immunodeficiency Virus

Source

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Identifiers

PMID: 23110705
DOI: 10.1186/1742-4690-9-89
PMCID: PMC3496648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23110705-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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