Article
Impaired cardiac contraction and relaxation and decreased expression of sarcoplasmic Ca2+-ATPase in mice lacking the CREM gene.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Jan 2003
Müller Frank U, Lewin Geertje, Matus Marek, Neumann Joachim, Riemann Burkhard, Wistuba Joachim, Schütz Günther, Schmitz Wilhelm
Abstract excerpt
Congestive heart failure is the common endpoint of various cardiac diseases representing a leading cause of cardiovascular mortality in Western countries. Characteristic functional alterations of the failing heart are explained by expressional changes of myocardial regulatory proteins; however, little is known about underlying mechanisms regulating cardiac gene expression in the failing heart. Here, we address...
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