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Article

Dysferlin deficiency blunts β-adrenergic-dependent lusitropic function of mouse heart.

The Journal of physiology - 1 Dec 2015

Wei Bin, Wei Hongguang, Jin J-P

Abstract excerpt

Dysferlin is a cell membrane bound protein with a role in the repair of skeletal and cardiac muscle cells. Deficiency of dysferlin leads to limb-girdle muscular dystrophy 2B (LGMD2B) and Miyoshi myopathy. In cardiac muscle, dysferlin is located at the intercalated disc and transverse tubule membranes. Loss of dysferlin causes death of cardiomyocytes, notably in ageing hearts, leading to dilated cardiomyopathy and...

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Identifiers

PMID: 26415898
DOI: 10.1113/JP271225
PMCID: PMC4666988

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