Article
Genetic variation near GRB10 associated with bone growth and osteosarcoma risk in canine and human populations.
Cancer epidemiology - 1 Oct 2024
Lucas Sydney E, Yang Tianzhong, Wimberly Courtney E, Parmar Kajal V, Hansen Helen M, de Smith Adam J, Morimoto Libby M, Metayer Catherine, Ostrom Quinn T, Eward William C, Graves Laurie A, Wagner Lars M, Wiemels Joseph L, Spector Logan G, Walsh Kyle M
Abstract excerpt
BACKGROUND: Canine and human osteosarcoma are similar in clinical presentation and tumor genomics. Giant breed dogs experience elevated osteosarcoma incidence, and taller stature remains a consistent risk factor for human osteosarcoma. Whether evolutionarily conserved genes contribute to both human and canine osteosarcoma predisposition merits evaluation. METHODS: A multi-center sample of childhood osteosarcoma...
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