Article
Genome-Wide Analyses for Osteosarcoma in Leonberger Dogs Reveal the CDKN2A/B Gene Locus as a Major Risk Locus.
Genes - 9 Dec 2021
Letko Anna, Minor Katie M, Norton Elaine M, Marinescu Voichita D, Drögemüller Michaela, Ivansson Emma, Megquier Kate, Noh Hyun Ji, Starkey Mike, Friedenberg Steven G, Lindblad-Toh Kerstin, Mickelson James R, Drögemüller Cord
Abstract excerpt
Dogs represent a unique spontaneous cancer model. Osteosarcoma (OSA) is the most common primary bone tumor in dogs (OMIA 001441-9615), and strongly resembles human forms of OSA. Several large- to giant-sized dog breeds, including the Leonberger, have a greatly increased risk of developing OSA. We performed genome-wide association analysis with high-density imputed SNP genotype data from 273 Leonberger cases with...
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